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KMID : 1155520110060020131
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Anesthesia and Pain Medicine
2011 Volume.6 No. 2 p.131 ~ p.137
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The optimal concentrations of propofol at eye opening and orientation after propofol-remifentanil TCI in Koreans
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Im Kyung-Sil
Kim Jong-Bun
Lee Jae-Myeong
Jung Hyun-Ju
Han Sang-Woo
Kim Dae-Woo
Ryu Keon-Hee
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Abstract
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Background: The recovery time in propofol target controlled infusion (TCI) can be determined by the context sensitive decrement time (CSDT) using a Multichannel TCI system. Therefore, it is important to obtain the default CSDT in a Multichannel TCI system. The effect-site concentrations for eye opening and orientation in adults after propofol-remifentanil TCI were evaluated according to the CSDT using a Multichannel TCI system.
Methods: After obtaining informed consent and Institutional Review Board approval, 135 ASA Class I or II patients scheduled to undergo elective surgery were divided into 3 groups according to age. The three groups included the following: group 1 (n = 45), 18?29 years; group 2 (n = 45), 30?39 years; and group 3 (n = 45), 40?54 years. The propofol infusion was started at a propofol target effect-site concentration (CeT) of 6?g/ml. Anesthesia was maintained primarily with a propofol CeT of 2.5?g/ml, a remifentanil CeT of 6 ng/ml and with 67% nitrous oxide in oxygen. The average effect-site concentrations of propofol at eye opening and orientation in each group were estimated.
Results: The average range of the effect-site concentrations of propofol at eye opening and orientation after surgery were 0.9?1.1 ?g/ml. The range of times to eye opening and orientation after stopping the nitrous oxide and infusion after surgery were 10.9?12.9 min.
Conclusions : The average range of the effect-site concentrations of propofol at eye opening and orientation after propofol-remifentanil TCI in Koreans are 0.9?1.1?g/ml.
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KEYWORD
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Intravenous anesthesia, Orientatio, Propofol, Remifentanil
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